义翘神州重组表达新冠病毒突变体将达到60多个

来源: 北京义翘神州科技有限公司   2020-8-26   访问量:462评论(0)

基因突变是病毒进化的基础。基因突变可以使病毒逃避宿主的免疫应答,并且可以更有利于病毒的传播。在一项新冠病毒研究中,Los Alamos National Laboratory的研究者发现最初出现在欧洲国家的新冠病毒的Spike抗原的一个重要的点突变---- D614G。D614G点突变毒株快速的成为欧洲国家主要的新冠病毒传染株。因此,对该突变体的生物特性认知就变得至关重要,尤其是在疫苗和治疗性药物开发过程中。

义翘神州开发出重组Spike S1 D614G突变体蛋白(40591-V08H3)。经过ELISA 结合试验证实,该重组S1突变体可与ACE2结合。

除了Spike D614突变体,新冠病毒基因组的其他一些突变位点很大程度上与Spike S1蛋白和ACE2的结合能力增加正相关。义翘神州开发了一系列的Spike 突变体蛋白以满足研究者们对新冠突变株的深入研究。

新冠Spike突变体蛋白

货号 产品名称
40591-V08H3 SARS-CoV-2 Spike S1-His tag (D614G)
40592-V08H7 SARS-CoV-2 Spike RBD-His tag (K458R)
40592-V08H6 SARS-CoV-2 Spike RBD-His tag (F342L)
40592-V08H1 SARS-CoV-2 Spike RBD-His tag (V367F)
40592-V05H1 SARS-CoV-2 Spike RBD-mFc tag (V367F)
40592-V08H2 SARS-CoV-2 Spike RBD-His tag (N354D)
40592-V08H4 SARS-CoV-2 Spike RBD-His tag (A435S)
40592-V08H5 SARS-CoV-2 Spike RBD-His tag (V483A)
40592-V08H9 SARS-CoV-2 Spike RBD-His tag (W436R)
40592-V08H8 SARS-CoV-2 Spike RBD-His tag (G476S)
40592-V08H10 SARS-CoV-2 Spike RBD-His tag (R408I)
40592-V08H11 SARS-CoV-2 Spike RBD-His tag (V341I)
40592-V08H12 SARS-CoV-2 Spike RBD-His tag (Y508H)
40592-V08H14 SARS-CoV-2 Spike RBD-His tag (N439K)
40592-V08H15 SARS-CoV-2 Spike RBD-His tag (V503F)
40592-V08H16 SARS-CoV-2 Spike RBD-His tag (A522V)
40592-V08H18 SARS-CoV-2 Spike RBD-His tag (S494P)
40592-V08H19 SARS-CoV-2 Spike RBD-His tag (A372S)
40592-V08H20 SARS-CoV-2 Spike RBD-His tag (A520S)
40592-V08H21 SARS-CoV-2 Spike RBD-His tag (A522S)
40592-V08H22 SARS-CoV-2 Spike RBD-His tag (D405V, Q414A)
40592-V08H23 SARS-CoV-2 Spike RBD-His tag (Q414E)
40592-V08H24 SARS-CoV-2 Spike RBD-His tag (P384L)
40592-V08H25 SARS-CoV-2 Spike RBD-His tag (A348S)
40592-V08H26 SARS-CoV-2 Spike RBD-His tag (F338L)
40592-V08H27 SARS-CoV-2 Spike RBD-His tag (F377L)
40592-V08H28 SARS-CoV-2 Spike RBD-His tag (L452R)
40592-V08H29 SARS-CoV-2 Spike RBD-His tag (P521S)
40592-V08H30 SARS-CoV-2 Spike RBD-His tag (T478I)
40592-V08H31 SARS-CoV-2 Spike RBD-His tag (V483I)
40592-V08H32 SARS-CoV-2 Spike RBD-His tag (S359N)
40592-V08H33 SARS-CoV-2 Spike RBD-His tag (K378R)
40592-V08H34 SARS-CoV-2 Spike RBD-His tag (Q409E)
40592-V08H35 SARS-CoV-2 Spike RBD-His tag (I472V)
40592-V08H36 SARS-CoV-2 Spike RBD-His tag (A372T)
40592-V08H37 SARS-CoV-2 Spike RBD-His tag (A344S)
40592-V08H39 SARS-CoV-2 Spike RBD-His tag (A520V)
40592-V08H40 SARS-CoV-2 Spike RBD-His tag (E406Q)
40592-V08H41 SARS-CoV-2 Spike RBD-His tag (F490S)
40592-V08H42 SARS-CoV-2 Spike RBD-His tag (K378N)
40592-V08H43 SARS-CoV-2 Spike RBD-His tag (N370S)
40592-V08H44 SARS-CoV-2 Spike RBD-His tag (Q414R)
40592-V08H45 SARS-CoV-2 Spike RBD-His tag (S477I)
40592-V08H46 SARS-CoV-2 Spike RBD-His tag (S477N)
40592-V08H47 SARS-CoV-2 Spike RBD-His tag (T385A)
40592-V08H48 SARS-CoV-2 Spike RBD-His tag (T393P)
40592-V08H49 SARS-CoV-2 Spike RBD-His tag (V395I)
40592-V08H52 SARS-CoV-2 Spike RBD-His tag (G485S)
40592-V08H53 SARS-CoV-2 Spike RBD-His tag (G482S)
40592-V08H54 SARS-CoV-2 Spike RBD-His tag (K444R)
40592-V08H55 SARS-CoV-2 Spike RBD-His tag (N440K)
40592-V08H56 SARS-CoV-2 Spike RBD-His tag (E471Q)
40592-V08H57 SARS-CoV-2 Spike RBD-His tag (P479S)
40592-V08H58 SARS-CoV-2 Spike RBD-His tag (A352S)
40592-V08H59 SARS-CoV-2 Spike RBD-His tag (K417N)
40592-V08H62 SARS-CoV-2 Spike RBD-His tag (P337S)
40592-V08H63 SARS-CoV-2 Spike RBD-His tag (P521R)
40592-V08H64 SARS-CoV-2 Spike RBD-His tag (S477R)
40591-V02H3 SARS-CoV-2 Spike S1 ECD-Fc (D614G)
40589-V08H4 SARS-CoV-2 Spike S1+S2 ECD tag (R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P)



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